Reaction: HAO2 tetramer oxidises 2OH-PALM
- in pathway: Peroxisomal lipid metabolism
Fatty acids can be metabolised by two distinct pathways; alpha- and beta-oxidation. Peroxisomal hydroxyacid oxidase 2 (HAO2) is thought to take part in alpha-oxidation of long chain fatty acids such as 2-hydroxypalmitate (2OH-PALM). HAO2 functions as a homotetramer and is highly expressed in liver and kidney (Jones et al. 2000).
Reaction - small molecule participants:
H2O2 [peroxisomal matrix]
2oxo-PALM [peroxisomal matrix]
O2 [peroxisomal matrix]
2OH-PALM [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6787811
======
Reaction input - small molecules:
dioxygen
2-hydroxyhexadecanoic acid
Reaction output - small molecules:
hydrogen peroxide
2-oxohexadecanoic acid
Reactome.org link: R-HSA-6787811