Reaction: HDHD1:Mg2+ dephosphorylates PURIDP
- in pathway: Pyrimidine salvage
Pseudouridine 5'-phosphate (PURIDP) is a potential intermediate in RNA degradation. Pseudouridine 5'-phosphatase (HDHD1) is a Mg2+-dependent enzyme present in erythrocytes that can dephosphorylate PURIDP to pseudouridine (PURID), the fifth-most abundant nucleoside in RNA. PURID is not metabolised in mammals but excreted intact in urine (Preumont et al. 2010).
Reaction - small molecule participants:
Pi [cytosol]
PURID [cytosol]
H2O [cytosol]
PURIDP [cytosol]
Reactome.org reaction link: R-HSA-6788295
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Reaction input - small molecules:
water
pseudouridine 5'-phosphate
Reaction output - small molecules:
hydrogenphosphate
pseudouridine
Reactome.org link: R-HSA-6788295