Reaction: HVEM induses BTLA phosphorylation
- in pathway: Costimulation by the CD28 family
Binding of HVEM to BTLA induces tyrosine phosphorylation of BTLA on three cytoplasmic tyrosines. The phosphorylated tyrosine Y274 and 299 ( Y257 and 282 in human BTLA) associate with tyrosine phosphatase SHP2 and down regulate proximal TCR signalling. Phosphorylated Y245 (Y226 in human BTLA) in BTLA associates with growth receptor bound 2 (GRB2) (Murphy et al. 2006).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6790087
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6790087