Reaction: LIPH, I hydrolyse PA to 2-acyl LPA
- in pathway: Synthesis of PA
Lipase members H and I (LIPH, I) specifically hydrolyse phosphatidic acid (PA) to the potent bioactive lipid mediator 2-acyl lysophosphatidic acid (2-acyl LPA) (Hiramatsu et al. 2003, Sonoda et al. 2002). LIPH is expressed in most tissues at low levels whereas LIPI is mainly expressed in the testis.
Reaction - small molecule participants:
2-acyl LPA [plasma membrane]
LCFA(-) [plasma membrane]
H2O [extracellular region]
PA [plasma membrane]
Reactome.org reaction link: R-HSA-6792445
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Reaction input - small molecules:
water
phosphatidate(2-)
Reaction output - small molecules:
2-acyl-sn-glycero-3-phosphate
long-chain fatty acid anion
Reactome.org link: R-HSA-6792445