Reaction: TORC2 complex phosphorylates SGK1
- in pathway: PIP3 activates AKT signaling
The TORC2 complex phosphorylates SGK1 at serine residue S422, located in the carboxy-terminal hydrophobic motif of SGK1. Phosphorylation at S422 contributes to SGK1 activation (Garcia-Martinez and Alessi 2008, Lu et al. 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6795290
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-6795290