Reaction: BPGM dimer isomerises 1,3BPG to 2,3BPG
- in pathway: Glycolysis
Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific trifunctional enzyme. One of its functions is the isomerisation of 1,3-bisphosphoglycerate (1,3BPG) to 2,3-bisphosphoglycerate (2,3BPG) (Rose 1968). In red blood cells, 2,3BPG is the main allosteric effector of hemoglobin, binding preferentially to the deoxygenated hemoglobin tetramer, thus reducing oxygen affinity (Arnone 1972).
Reaction - small molecule participants:
2,3BPG [cytosol]
1,3BPG [cytosol]
Reactome.org reaction link: R-HSA-6798335
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Reaction input - small molecules:
3-phosphonato-D-glyceroyl phosphate(4-)
Reaction output - small molecules:
2,3-bisphosphoglycerate
Reactome.org link: R-HSA-6798335