Reaction: ATM phosphorylates DYRK2
- in pathway: Regulation of TP53 Activity through Phosphorylation
Activated ATM kinase phosphorylates DYRK2 at threonine residue T106 (matching T33 in the shorter splicing isoform of DYRK2) and serine residue S442 (matching S369 in the shorter splicing isoform of DYRK2). ATM-mediated phosphorylation of DYRK2 prevents DYRK2 ubiquitination by MDM2 and the consequent DYRK2 degradation (Taira et al. 2010).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6798372
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6798372