Reaction: ATM phosphorylates ZNF420
Activated ATM phosphorylates ZNF420 (Apak) at serine residue S68. Phosphorylation at S68 inhibits ZNF420 binding to the first intron of TP53AIP1 (p53AIP1) gene, thus facilitating TP53 (p53)-mediated expression of TP53AIP1 (Yuan et al. 2012). ATM-mediated phosphorylation of ZNF420 also inhibits ZNF420 interaction with TP53 and the consequent TP53 deacetylation (Tian et al. 2009).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6799097
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6799097