Reaction: CHEK1 phosphorylates TP53
- in pathway: G2/M DNA damage checkpoint
CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).
Reaction - small molecule participants:
ATP [nucleoplasm]
ADP [nucleoplasm]
ATP [nucleoplasm]
ADP [nucleoplasm]
Reactome.org reaction link: R-HSA-6799246
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-6799246