Reaction: HIPK2 phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
HIPK2, activated by autophosphorylation in response to DNA damage, phosphorylates TP53 (p53) at serine residue S46 (D'Orazi et al. 2002, Hofmann et al. 2002). A TP53 transcriptional target TP53INP1 facilitates TP53 phosphorylation at S46 in response to double strand breaks and, together with HIPK2, promotes the transcription of TP53 apoptotic gene targets (Okamura et al. 2001, Tomasini et al. 2003).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6799409
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6799409