Reaction: GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P
- in pathway: Glycolysis
Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).
Reaction - small molecule participants:
Fru(6)P [cytosol]
NH4+ [cytosol]
H2O [cytosol]
GlcN6P [cytosol]
Reactome.org reaction link: R-HSA-6799604
======
Reaction input - small molecules:
water
alpha-D-glucosamine 6-phosphate
Reaction output - small molecules:
beta-D-fructofuranose 6-phosphate(2-)
ammonium
Reactome.org link: R-HSA-6799604