Reaction: HGFAC cleaves pro-HGF to form HGF dimer
- in pathway: MET Receptor Activation
HGF is a pleiotropic factor and activates hepatocyte growth factor receptor (MET), a proto-oncogenic receptor tyrosine kinase. HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage at Arg494–Val495 to form the biologically active alpha-beta heterodimer. Hepatocyte growth factor activator (HGFAC, commonly known as HGFA) is a serine protease that converts HGF into its active form (Shia et al. 2005). The Kunitz-type protease inhibitor 1 (SPINT1, aka HAI1) is an inhibitor of HGFAC activity (Shia et al. 2005).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-6800299
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-6800299