Meta-Biol

• Pathways

Triacylglycerol (TG) is a non-polar acyl triester of glycerol and fatty acids. TG serves primarily as a reservoir of fatty acids for energy production. TG synthesis in all organisms occurs via the conserved canonical pathway known as the Kennedy or sn-glycerol-3-phosphate (G3P) pathway. Diacylglycerol (DAG), an intermediate in the Kennedy pathway, can also enter this pathway via an alternative route known as the remodeling pathway which dominates in the small intestine where most dietary fat is absorbed. In this pathway, monoacylglycerol is acylated, mediated by monoacylglycerol acyltransferases 1, 2 and 3 (MOGAT1, 2 and 3) to form DAG (Winter et al. 2003, Lockwood et al. 2003, Cheng et al. 2003, Yu et al. 2015).