Reaction: Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
- in pathway: Signaling by high-kinase activity BRAF mutants
Highly active BRAF mutants show constitutive phosphorylation of MAPKs that does not depend on RAS activation or RAF dimerization (Davies et al, 2002; Wan et al, 2004; Garnett et al, 2005; reveiwed in Lavoie and Therrien, 2015).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6802910
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6802910