Reaction: High kinase activity BRAF complexes phosphorylate MAP2Ks
- in pathway: Signaling by high-kinase activity BRAF mutants
Highly active BRAF mutants such as V600E are constitutively active and phosphorylate MAP2Ks in a RAS- and dimer interface-independent manner (Davies et al, 2002; Wan et al, 2004; Garnett et al, 2005; Roring et al, 2012; Poulikakos et al, 2010; reviewed in Lavoie and Therrien, 2015).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6802911
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6802911