Reaction: RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
- in pathway: Signaling by moderate kinase activity BRAF mutants
Recruitment of MAP2Ks and MAPKs downstream of moderately activated BRAF mutants leads to phosphorylation and activation of MAP2Ks, as in the WT pathway (Wan et al, 2004; Freeman et al, 2013; Roring et al, 2012; reviewed in Lavoie and Therrien, 2015).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6802919
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6802919