Reaction: Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
- in pathway: Signaling by moderate kinase activity BRAF mutants
MAPKs are phosphorylated downstream of moderately activated BRAF mutants in a MAP2K-dependent manner (Wan et al, 2004; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6802921
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6802921