Reaction: RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
As in the WT pathway, activation of ERK signaling downstream of kinase-dead or inhibited forms of BRAF depends on phosphorylation of two serine residues in the activation loop of the MAP2K proteins (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6802943
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6802943