Reaction: Nitrite ion and HNO2 form a conjugated acid-base pair
- in pathway: ROS and RNS production in phagocytes
In the acidic conditions nitrite (NO2-) and nitrous acid (HNO2) present as a conjugated acid-base pair. HNO2 can further react with an additional HNO2 to produce N2O3 (Oldreive C & Rice-Evans C. 2001). N2O3 formation regulates the function of many target proteins through the coupling of a nitroso moiety (NO+) to a reactive cysteine, ultimately leading to the formation of RSNO, a process commonly known as S-nitrosylation (Broniowska KA & Hogg N 2012).
Reaction - small molecule participants:
HNO2 [phagocytic vesicle lumen]
H+ [phagocytic vesicle lumen]
nitrite [phagocytic vesicle lumen]
Reactome.org reaction link: R-HSA-6803998
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Reaction input - small molecules:
hydron
nitrite
Reaction output - small molecules:
nitrous acid
Reactome.org link: R-HSA-6803998