Reaction: CHEK2 phosphorylates TTC5
- in pathway: Regulation of TP53 Activity through Methylation
CHEK2 phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S221, resulting in TTC5 stabilization through an unknown mechanism (Adams et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6804266
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6804266