Reaction: AURKA phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
AURKA (Aurora kinase A) phosphorylates TP53 (p53) on serine residue S315. This leads to destabilization of TP53 by enhancing MDM2 binding (Katayama et al. 2004). Based on Xenopus studies, AURKA-mediated phosphorylation of TP53 occurs in the presence of AURKA activator TPX2 (Pascreau et al. 2009).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6805103
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6805103