Reaction: AURKB phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
AURKB (Aurora kinase B) phosphorylates TP53 (p53) at serine residue S269 and threonine residue T284, which inhibits TP53 transcriptional activity (Wu et al. 2011).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6805126
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6805126