Reaction: GPR35 binds kynurenic acid
- in pathway: Class A/1 (Rhodopsin-like receptors)
GPR35 is expressed both in neurons and other cells (including glia, macrophages and monocytes). KYNA has been proposed as the endogenous agonist of GPR35 (Wang et al. 2006).
Kynurenic acid (KYNA) is a tryptophan metabolite (Moroni 1999). It can selectively antagonize NMDA type glutamate receptors (Perkins & Stone 1982).
Kynurenic acid (KYNA) is a tryptophan metabolite (Moroni 1999). It can selectively antagonize NMDA type glutamate receptors (Perkins & Stone 1982).
Reaction - small molecule participants:
Kynurenic acid [extracellular region]
Reactome.org reaction link: R-HSA-6805205
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Reaction input - small molecules:
kynurenic acid
Reaction output - small molecules:
Reactome.org link: R-HSA-6805205