Reaction: CDK5 phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
CDK5, in complex with cleaved CDK5R1 (p25), which ensures nuclear localization (Patrick et al. 1999, Lee et al. 2008), phosphorylates TP53 (p53) on serine residues S15, S33 and S46. CDK5-mediated phosphorylation of TP53 promotes transcription of pro-apoptotic genes and neuronal cell death (Zhang et al. 2002, Lee et al. 2007, Lee et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6805276
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6805276