Reaction: TAF1 phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
TAF1, the largest subunit of the transcription initiation factor TFIID complex, phosphorylates TP53 (p53) at threonine residue T55. TAF1-mediated phosphorylation of TP53 increases affinity of TP53 for the ubiquitin ligase MDM2, thus promoting TP53 degradation (Li et al. 2004).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6805399
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6805399