Reaction: AMPK phosphorylates TP53
- in pathway: Regulation of TP53 Activity through Phosphorylation
AMPK, activated in response to glucose deprivation, phosphorylates TP53 (p53) on serine residue S15, initiating AMPK-dependent cell cycle arrest (Jones et al. 2005). AMPK-dependent phosphorylation of TP73 (p73) appears to be involved in TP53 stabilization upon AMPK activation (Adamovich et al. 2014).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6805470
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6805470