Reaction: MTA2-NuRD complex deacetylates TP53
- in pathway: Regulation of TP53 Activity through Acetylation
MTA2 (PID), a component of the NuRD complex, binds TP53 (p53) and thus targets histone deacetylases of the NuRD complex to TP53. The NuRD complex deacetylates the C-terminus of TP53, including acetylated lysine K382, thus inhibiting TP53 transcriptional activity (Luo et al. 2000).
Reaction - small molecule participants:
acetate [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-6805650
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Reaction input - small molecules:
water
Reaction output - small molecules:
acetate
Reactome.org link: R-HSA-6805650