Reaction: UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)
- in pathway: Metabolism of vitamin K
UBIAD1 (UbiA prenyltransferase domain-containing protein 1) in the endoplasmic reticulum catalyzes the transfer of a geranylgeranyl group from GGPP (geranylgeranyl pyrophosphate)to menadione to form MK4 (vitamin K hydroquinone, menatetrenone) (Nakagawa et al. 2010; Hirota et al. 2013, 2015; Schumacher et al. 2015).
Reaction - small molecule participants:
MK4 [endoplasmic reticulum lumen]
PPi [endoplasmic reticulum lumen]
menadione [endoplasmic reticulum lumen]
GGPP [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-6806674
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Reaction input - small molecules:
menadione
geranylgeranyl diphosphate(3-)
Reaction output - small molecules:
menaquinone-4
diphosphate(3-)
Reactome.org link: R-HSA-6806674