Reaction: CYB5Rs reduce MetHb to HbA
- in pathway: Erythrocytes take up carbon dioxide and release oxygen
NADH-Cytochrome b5 reductases (CYB5Rs), flavoproteins consisting of NADH and flavin adenine dinucleotide (FAD) binding domains, catalyse electron transfer from the two-electron carrier NADH to the one-electron carrier ferricytochrome b5 ((Fe(3+)Cb5), forming ferrocytochrome b5 ((Fe(2+)Cb5) (Zhu et al. 1999, Baker et al. 2005, Zhu et al. 2004). CYB5Rs participate in fatty acid synthesis, cholesterol synthesis and xenobiotic oxidation as members of the electron transport chain on the endoplasmic reticulum membrane. In erythrocytes, CYB5Rs participate in the reduction of methemoglobin (MetHb) to hemoglobin A (HbA).
Reaction - small molecule participants:
H+ [cytosol]
NAD+ [cytosol]
NADH [cytosol]
Reactome.org reaction link: R-HSA-6806831
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Reaction input - small molecules:
NADH(2-)
Reaction output - small molecules:
hydron
NAD(1-)
Reactome.org link: R-HSA-6806831