Reaction: APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX
- in pathway: Nicotinamide salvaging
NAD(P)H-hydrate epimerase (APOA1BP) is a homodimeric protein located in the mitochondrion (Ritter et al. 2002). Mammalian APOA1BP is able to mediate the epimerisation of the R-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (Marbaix et al. 2011). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Reaction - small molecule participants:
S-NADPHX [mitochondrial matrix]
R-NADPHX [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6806966
======
Reaction input - small molecules:
(R)-NADPHX
Reaction output - small molecules:
(S)-NADPHX
Reactome.org link: R-HSA-6806966