Reaction: CARKD dehydrates S-NAD(P)HX to NADPH
- in pathway: Nicotinamide salvaging
Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).
Reaction - small molecule participants:
Pi [mitochondrial matrix]
ADP [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
ATP [mitochondrial matrix]
S-NADPHX [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6806967
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Reaction input - small molecules:
ATP(4-)
(S)-NADPHX
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
hydron
NADPH
Reactome.org link: R-HSA-6806967