Meta-Biol

• Pathways

The activated MET receptor autophosphorylates on four tyrosine residues. Two tyrosines, Y1234 and Y1235 are located in the kinase domain of MET and their phosphorylation increases the catalytic activity of MET. Y1235 is the major phosphorylation site (Ferracini et al. 1991, Longati et al. 1994, Rodrigues and Park 1994). The other two MET tyrosines that undergo autophosphorylation are Y1349 and Y1356. These two tyrosines are at the C-terminus of MET and serve as docking sites for binding of MET effectors (Ponzetto et al. 1994, Weidner et al. 1995). It is uncertain whether tyrosine residue Y1365 is also autophosphorylated.