Reaction: PTPRJ dephosphorylates MET
- in pathway: Negative regulation of MET activity
PTPRJ (DEP1) protein tyrosine phosphatase dephosphorylates MET tyrosine residue Y1349. As Y1349 is a GAB1 docking site, PTPRJ-mediated dephosphorylation of MET prevents GAB1 binding to MET and activation of MET-initiated GAB1 signaling. PTPRJ can also dephosphorylate MET at Y1365, which is of unknown importance (Palka et al. 2003).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-6807008
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-6807008