Reaction: USP7 deubiquitinates monoubiquitinated PTEN
- in pathway: Regulation of PTEN localization
USP7 (HAUSP) deubiquitinates monoubiquitinated nuclear PTEN, thus promoting relocalization of PTEN to the cytosol. USP7-mediated deubiquitination of PTEN is negatively regulated by PML in the presence of DAXX, but the exact mechanism has not been elucidated (Song et al. 2008).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-6807118
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-6807118