Reaction: USP13 and OTUD3 deubiquitinate PTEN
- in pathway: Regulation of PTEN stability and activity
Several ubiquitin proteases deubiquitinate polyubiquitinated PTEN. USP13 and OTUD3 prolong the half-life of PTEN by preventing its proteasome-mediated degradation. Loss of USP13 or OTUD3 expression promotes AKT activation and cancer aggressiveness (Zhang et al. 2013, Yuan et al. 2015).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-6807206
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-6807206