Reaction: GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)
- in pathway: Gamma-carboxylation of protein precursors
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates three glutamate residues on BGLAP(24-100) (pro-osteocalcin). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Ferron et al. 2015; Furie et al. 1999; Hauschka et al. 1989; Morris et al. 1995; oser et al. 1980; Stenina et al. 2001).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
MK4 epoxide [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
MK4 [endoplasmic reticulum lumen]
CO2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-6807214
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Reaction input - small molecules:
dioxygen
menaquinone-4
carbon dioxide
Reaction output - small molecules:
water
2,3-epoxymenatetrenone
Reactome.org link: R-HSA-6807214