Reaction: LDHAL6B reduces PYR to LACT
- in pathway: Pyruvate metabolism
LDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the reaction of PYR (pyruvate) and NADH + H+ to form LACT (lactate) and NAD+. The LDHAL6B protein is the inferred product of an open reading frame transcribed in the testis (Wang et al. 2005). Its mitochondrial localization is inferred from the presence of a mitochondrial localization sequence at its amino terminus (Holmes and Goldberg 2009). A physiological role for lactate formation from the abundant pyruvate and NADH expected in rapidly respiring mitochondria is not straightforward to imagine, however.
Reaction - small molecule participants:
NAD+ [mitochondrial matrix]
LACT [mitochondrial matrix]
H+ [mitochondrial matrix]
PYR [mitochondrial matrix]
NADH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6807826
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Reaction input - small molecules:
hydron
pyruvate
NADH(2-)
Reaction output - small molecules:
NAD(1-)
(S)-lactic acid
Reactome.org link: R-HSA-6807826