Reaction: ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG
- in pathway: Metabolism of folate and pterines
ALDH1L2 (mitochondrial 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of mitochondrial biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).
Reaction - small molecule participants:
H+ [mitochondrial matrix]
THFPG [mitochondrial matrix]
NADPH [mitochondrial matrix]
CO2 [mitochondrial matrix]
NADP+ [mitochondrial matrix]
10-formyl-THFPG [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6808487
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Reaction input - small molecules:
NADP(+)
10-formyltetrahydrofolyl polyglutamate macromolecule
water
Reaction output - small molecules:
hydron
tetrahydrofolyl-poly(glutamic acid) macromolecule
NADPH
carbon dioxide
Reactome.org link: R-HSA-6808487