Reaction: NUDT12 hydrolyses NADH to NMNH
- in pathway: Nicotinamide salvaging
The human nudix hydrolase peroxisomal NADH pyrophosphatase (NUDT12) shows in vitro hydrolase activity towards NAD(P)H, NAD(P)+, ADP-ribose and diadenosine triphosphate. Like other NADH diphosphatases of the Nudix family, NUDT12 has a marked substrate preference for reduced nicotinamide nucleotides. It can hydrolyse NAD(H) to the nicotinamide mononucleotide NMN(H) and may act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism here (Abdelraheim et al. 2003).
Reaction - small molecule participants:
NMNH [peroxisomal matrix]
H+ [peroxisomal matrix]
H2O [peroxisomal matrix]
NADH [peroxisomal matrix]
AMP [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6809287
======
Reaction input - small molecules:
water
NADH(2-)
adenosine 5'-monophosphate(2-)
Reaction output - small molecules:
NMNH(2-)
hydron
Reactome.org link: R-HSA-6809287