Reaction: NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT
- in pathway: Peroxisomal lipid metabolism
Coenzyme A (CoASH) is a necessary cofactor for the oxidation of lipids in peroxisomes. Peroxisomal coenzyme A diphosphatase (NUDT7) mediates the cleavage of CoA (and CoA esters and oxidised CoA) to produce 3',5'-ADP and 4'-phosphopantetheine (PPANT) and is suggested to be involved in the regulation of peroxisomal CoASH levels. Human NUDT7 activity is inferred from mouse Nudt7 activity (Gasmi et al. 2001, Reilly et al. 2008).
Reaction - small molecule participants:
PPANT [peroxisomal matrix]
3',5'-ADP [peroxisomal matrix]
H2O [peroxisomal matrix]
CoA-SH [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6809354
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Reaction input - small molecules:
water
coenzyme A(4-)
Reaction output - small molecules:
D-pantetheine 4'-phosphate(2-)
adenosine 3',5'-bisphosphate
Reactome.org link: R-HSA-6809354