Reaction: PI3P is dephosphorylated to PI by MTM1:MTMR12
- in pathway: Synthesis of PIPs at the early endosome membrane
Binding of MTMR12 to MTM1 enhances phosphatidylinositol-3-phosphatase activity of MTM1 at cytosolic vesicular structures, presumably early or late endosomes (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).
Reaction - small molecule participants:
Pi [cytosol]
PI [early endosome membrane]
H2O [cytosol]
PI3P [early endosome membrane]
Reactome.org reaction link: R-HSA-6809720
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol(1-)
Reactome.org link: R-HSA-6809720