Reaction: PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1
- in pathway: Synthesis of PIPs at the ER membrane
Formation of the complex with SBF1 (MTMR5) increases phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR2 (Kim et al. 2003). SBF1 promotes perinuclear localization of MTMR2 (Kim et al. 2003), presumably to the endoplasmic reticulum(ER) membrane, as both proteins can localize to the ER membrane (Berger et al. 2003, Li et al. 2014).
Reaction - small molecule participants:
Pi [cytosol]
PI5P [endoplasmic reticulum membrane]
H2O [cytosol]
PI(3,5)P2 [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-6809778
======
Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
Reactome.org link: R-HSA-6809778