Reaction: ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA
- in pathway: Beta-oxidation of very long chain fatty acids
ECI2 in the peroxisome matrix catalyzes the isomerizeation of 3Z-enoyl-CoA to 2E-enoyl-CoA. The active form of the enzyme is a homotrimer (Onwukwe et al. 2015). The reaction annotated here, involving octenoyl-CoA isomers is the one originally characterized by Geisbreacht et al. (1999), although the enzyme is active on enoyl-CoAs of a range of chain lengths.
Reaction - small molecule participants:
2E-octenoyl-CoA [peroxisomal matrix]
3Z-octenoyl-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6809808
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Reaction input - small molecules:
cis-3-octenoyl-CoA
Reaction output - small molecules:
trans-oct-2-enoyl-CoA
Reactome.org link: R-HSA-6809808