Reaction: PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA
- in pathway: Alpha-oxidation of phytanate
PECR associated with the peroxisomal membrane catalyzes the NADPH-dependent reduction of 2E-phytenoyl-CoA to form phytanoyl-CoA (Das et al. 2000; Gloerich et al. 2006). The active form of the enzyme is inferred to be a homotetramer from unpublished data deposited in PDB (accession 1YXM). This reaction is part of the process by which dietary phytol, ultimately derived from chlorophyll, is catabolized (Van Veldhoven 2010).
Reaction - small molecule participants:
Phytanoyl-CoA [peroxisomal matrix]
NADP+ [peroxisomal matrix]
H+ [peroxisomal matrix]
NADPH [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6809810
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Reaction input - small molecules:
hydron
NADPH
Reaction output - small molecules:
phytanoyl-CoA
NADP(+)
Reactome.org link: R-HSA-6809810