Reaction: PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane
- in pathway: Synthesis of PIPs at the plasma membrane
Formation of a complex with SBF2 (MTMR13) dramatically increases phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR2. Since SBF2 sequesters MTRM2 from endosome membranes, the MTMR2 presumably acts on the plasma membrane-associated substrate (Berger et al. 2006).
Reaction - small molecule participants:
Pi [cytosol]
PI5P [plasma membrane]
H2O [cytosol]
PI(3,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-6809944
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
Reactome.org link: R-HSA-6809944