Reaction: CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
- in pathway: RNA polymerase II transcribes snRNA genes
CDK7 phosphorylates serine-5 residues of heptad repeats (consensus YSPTSPS) in the C-terminal domain (CTD) of the large subunit (POLR2A) of RNA polymerase II. Serine-7 residues of the heptad repeats are also phosphorylated at promoters of snRNA genes (Egloff et al. 2007) and CDK7 is required for phosphorylation of serine-7 in vivo (Glover-Cutter et al. 2009). P-TEFb and DNA-PK are able to phosphorylate serine-7 in vitro (Glover-Cutter et al. 2009, Egloff et al. 2010). Impairment of CTD phosphorylation does not appear to affect transcription of snRNA genes but rather impairs 3' processing of the pre-snRNA (Medlin et al. 2003, Jacobs et al. 2004).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-6810233
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-6810233