Reaction: NUDT14 hydrolyses UDP-Glc to G1P and UMP
- in pathway: Synthesis of dolichyl-phosphate-glucose
Uridine diphosphate glucose pyrophosphatase (NUDT14) is a member of the Nudix hydrolase family, a ubiquitously distributed group of nucleotide pyrophosphatases. NUDT14 hydrolyses UDP-glucose (UDP-Glc) to glucose 1-phosphate (G1P) and UMP. UDP-Glc is a sugar donor in many glycosylation reactions and a cytosolic pyrophosphatase such as NUDT14 could play a role in regulating gluconeogenesis (Yagi et al. 2003).
Reaction - small molecule participants:
G1P [cytosol]
UMP [cytosol]
H2O [cytosol]
UDP-D-glucose(2-) [cytosol]
Reactome.org reaction link: R-HSA-6810464
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Reaction input - small molecules:
water
UDP-D-glucose(2-)
Reaction output - small molecules:
D-glucopyranose 1-phosphate(2-)
uridine 5'-monophosphate(2-)
Reactome.org link: R-HSA-6810464