Reaction: NUDT13 hydrolyses AP6A to AP4 and ADP
- in pathway: Interconversion of nucleotide di- and triphosphates
Mitochondrial Nudix hydrolase 13 (NUDT13) is able to hydrolyse long-chain diadenosine polyphosphates such as diadenosine hexaphosphate (AP6A) to ADP and adenosine tetraphosphate (AP4). Human NUDT13 activity is inferred from Nudt13 activity in Arabidopsis thaliana (Olejnik et al. 2007). Diadenosine polyphosphates play a role in the cardiovascular system with potential involvement in mediating the pathophysiological effects associated with platelet activation during myocardial ischaemia.
Reaction - small molecule participants:
ADP [mitochondrial matrix]
AP4 [mitochondrial matrix]
AP6A [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-6810472
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Reaction input - small molecules:
P(1),P(6)-bis(5'-adenosyl)hexaphosphate(6-)
water
Reaction output - small molecules:
ADP(3-)
adenosine 5'-tetraphosphate(5-)
Reactome.org link: R-HSA-6810472