Reaction: NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT
- in pathway: Peroxisomal lipid metabolism
Coenzyme A (CoA-SH) and acyl-coenzyme A (acyl-CoA) can be degraded in peroxisomes by two members of the Nudix (nucleoside diphosphates linked to some moiety X) hydrolase superfamily; NUDT7 and NUDT19. NUDT19 hydrolyses free fatty acyl-CoA to form acyl-phosphopantetheine (acyl-PPANT) and 3′,5′-ADP. Human NUDT19 activity is inferred from mouse Nudt19 activity (Ofman et al. 2006).
Reaction - small molecule participants:
3',5'-ADP [peroxisomal matrix]
acyl-PPANT [peroxisomal matrix]
H2O [peroxisomal matrix]
FA-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-6810474
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Reaction input - small molecules:
water
fatty acyl-CoA(4-)
Reaction output - small molecules:
adenosine 3',5'-bisphosphate
S-acylpantetheine 4'-phosphate group
Reactome.org link: R-HSA-6810474