Reaction: NSF ATPase activity dissociates cis-SNARE at the ER
- in pathway: COPI-dependent Golgi-to-ER retrograde traffic
NSF-dependent hydrolysis of ATP is required to disassociate the cis-SNARE complex, releasing the SNAREs for further rounds of membrane fusion (Mayer et al, 1996; Muller et al, 1999; Muller et al, 2002; Otto et al, 1997; Whiteheart et al, 2004; Yu et al, 1999; Zhao et al, 2012; Shah et al, 2015; reviewed in Sudhof and Rothman, 2009).
Reaction - small molecule participants:
Pi [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-6811422
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-6811422